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Pharmacokinetics of lidocaine and its metabolite in peridural anesthesia administered to pregnant women with gestational diabetes mellitus.
Moisés, Elaine Christine Dantas; Duarte, Luciana de Barros; Cavalli, Ricardo de Carvalho; Marques, Maria Paula; Lanchote, Vera Lúcia; Duarte, Geraldo; da Cunha, Sérgio Pereira.
Afiliação
  • Moisés EC; University Hospital, Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. elainemoises@hcrp.fmrp.usp.br
Eur J Clin Pharmacol ; 64(12): 1189-96, 2008 Dec.
Article em En | MEDLINE | ID: mdl-18679666
BACKGROUND: Peridural blockade with lidocaine, bupivacaine, and fentanyl is an anesthetic procedure extensively used in obstetrics, justifying the pharmacokinetic study of these drugs during labor. OBJECTIVE: To investigate the influence of the physiopathological changes of gestational diabetes mellitus (GDM) on the pharmacokinetics of lidocaine and its metabolite monoethylglycinexylidide (MEGX) in pregnant women subjected to peridural anesthesia. PATIENTS AND METHODS: Ten normal pregnant women (group 1) and six pregnant women with GDM (group 2) were studied, all of them at term. The patients received 200 mg 2% lidocaine hydrochloride without a vasoconstrictor by the peridural locoregional route. Maternal blood samples were collected at predetermined times for the analysis of lidocaine and MEGX by chromatography and pharmacokinetic analysis. RESULTS: The median pharmacokinetic parameters of lidocaine for groups 1 and 2 (P
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Gestacional / Anestesia Epidural / Anestésicos Locais / Lidocaína Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Eur J Clin Pharmacol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Gestacional / Anestesia Epidural / Anestésicos Locais / Lidocaína Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Eur J Clin Pharmacol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha