Subclinical infection as a cause of inflammation in preeclampsia.
Am J Ther
; 15(4): 373-6, 2008.
Article
em En
| MEDLINE
| ID: mdl-18645342
Preeclampsia, a pregnancy-exclusive hypertensive disorder, is the major cause of maternal and perinatal mortality, with a greater importance in developing countries. The role of inflammation in the pathogenesis of preeclampsia has been the object of recent studies by our group. We have described elevated levels of inflammatory markers (tumor necrosis factor alpha, interleukin-6, and C-reactive protein) in preeclamptic patients and demonstrated that Latin-American women present a higher degree of inflammation than women from developed countries. We have results that suggest that chronic subclinical infections and insulin resistance are the most probable causes of the increased inflammation in preeclampsia. Moreover, we showed that early treatment of urinary and vaginal infections decreased the incidence of preeclampsia. We also have evidence that suggests that inflammation leads to endothelial dysfunction, predisposing women to develop preeclampsia. Increased levels of inflammation markers and endothelial dysfunction are found in the early stages of pregnancy in women who later on develop preeclampsia. Appropriate prenatal care programs, including screening and treatment of urinary, vaginal, and periodontal infections in early pregnancy and prevention of factors that predispose to insulin resistance, such as excessive weight gain during pregnancy, may reduce the incidence of preeclampsia in Latin-American women.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Infecções Bacterianas
/
Inflamação
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Am J Ther
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Colômbia
País de publicação:
Estados Unidos