Conservation of key members in the course of the evolution of the insulin signaling pathway.
Biosystems
; 95(1): 7-16, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-18616978
Our understanding of the evolution of the insulin signaling pathway (ISP) is still incomplete. One intriguing unanswered question is the explanation of the emergence of the glucostatic role of insulin in mammals. To find out whether this is due to the development of new sets of signaling transduction elements in these organisms, or to the establishment of new interactions between pre-existing proteins, we rebuilt putative orthologous ISPs in 17 eukaryotic organisms. Then, we computed the conservation of orthologous ISPs at different levels, from sequence similarity of orthologous proteins to co-evolution of interacting domains. We found that the emergence of glucostatic role in mammals can neither be explained by the development of new sets of signaling elements, nor by the establishment of new interactions between pre-existing proteins. The comparison of orthologous IRS molecules indicates that only in mammals have they acquired their complete functionality as efficient recruiters of effector sub-pathways.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Evolução Molecular
/
Insulina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biosystems
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Cuba
País de publicação:
Irlanda