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Macrophage migration inhibitory factor (MIF) is critical for the host resistance against Toxoplasma gondii.
Flores, Marcos; Saavedra, Rafael; Bautista, Rocio; Viedma, Rubi; Tenorio, Eda P; Leng, Lin; Sánchez, Yuriko; Juárez, Imelda; Satoskar, Anjali A; Shenoy, Asha S; Terrazas, Luis I; Bucala, Richard; Barbi, Joseph; Satoskar, Abhay R; Rodriguez-Sosa, Miriam.
Afiliação
  • Flores M; Unidad de Biomedicina, FES-Iztacala, UNAM. Av. de los Barrios #1, Los Reyes Iztacala, 54090 Tlalnepantla, Mexico City, Mexico.
FASEB J ; 22(10): 3661-71, 2008 Oct.
Article em En | MEDLINE | ID: mdl-18606868
Macrophage migration inhibitory factor (MIF) exerts either a protective or a deleterious role in the immune response to different pathogens. We analyzed herein the role of MIF in the host control of toxoplasmosis using MIF(-/-) mice backcrossed to either the BALB/c or the C57BL/6 genetic backgrounds. Both, wild-type (WT) BALB/c and MIF(-/-) BALB/c mice were susceptible to infection with highly virulent RH as well as moderately virulent ME49 strains of T. gondii. MIF(-/-) mice, however, showed greater liver damage and more brain cysts, produced less proinflammatory cytokines, and succumbed significantly faster than WT mice. Bone marrow-derived dendritic cells (BMDCs) from MIF(-/-) mice produced less interleukin-1beta, interleukin-12, and tumor necrosis factor-alpha than WT BMDCs after stimulation with soluble Toxoplasma antigen (STAg). Similar observations were made in CD11c(+) low-density cells isolated from the spleens of MIF(-/-) mice challenged with STAg. MIF(-/-) C57BL/6 mice succumbed to ME49 infection faster than their WT counterparts. C57BL/6 mice that succumbed to infection with the ME49 strain produced less MIF than resistant BALB/c mice similarly infected. Interestingly, an analysis of brains from patients with cerebral toxoplasmosis showed low levels of MIF expression. Together, these findings demonstrate that MIF plays a critical role in mediating host resistance against T. gondii.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxoplasmose / Fatores Inibidores da Migração de Macrófagos / Oxirredutases Intramoleculares / Predisposição Genética para Doença / Interações Hospedeiro-Parasita / Imunidade Inata Limite: Animals / Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxoplasmose / Fatores Inibidores da Migração de Macrófagos / Oxirredutases Intramoleculares / Predisposição Genética para Doença / Interações Hospedeiro-Parasita / Imunidade Inata Limite: Animals / Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos