Distortion product otoacoustic emissions in sheep before and after hyperinsulinemia induction.
Braz J Otorhinolaryngol
; 74(2): 181-7, 2008.
Article
em En
| MEDLINE
| ID: mdl-18568194
UNLABELLED: Transient evoked otoacoustic emissions and distortion product otoacoustic emissions have gained significant importance in the identification of cochlear alterations. AIM: To record distortion product thresholds through the monitoring of otoacoustic emissions in normal conditions and in the presence of electrophysiologic changes in cochlear outer hair cells in sheep after hyperinsulinemia induction. MATERIAL AND METHODS: Experimental study, with seven sheep in the control group and seven in the study group. Insulin and glucose concentrations were measured simultaneously for the recording of distortion product otoacoustic emission every 10 minutes, all the way to 90 minutes. The control group received saline solution, and the study group received a bolus injection of 0.1 U/kg of regular human insulin. RESULTS: There was a significant reduction in distortion product thresholds in the study group when compared to the control group at frequencies greater than 1,500 Hz and after 60 minutes (P < 0.001). CONCLUSION: This study established distortion product otoacoustic emission thresholds in sheep with constant reproducibility, demonstrating that the method is adequate for use in audiology and otology investigations. Results also fully confirm that acute hyperinsulinemia may cause important changes in these thresholds.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Emissões Otoacústicas Espontâneas
/
Cóclea
/
Hiperinsulinismo
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Braz J Otorhinolaryngol
Assunto da revista:
OTORRINOLARINGOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil