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Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease.
Hammes, Luciano S; Tekmal, Rajeshwar Rao; Naud, Paulo; Edelweiss, Maria Isabel; Kirma, Nameer; Valente, Philip T; Syrjänen, Kari J; Cunha-Filho, João Sabino.
Afiliação
  • Hammes LS; Department of Obstetrics and Gynecology, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. lucianohammes@gmail.com
Gynecol Oncol ; 110(3): 445-51, 2008 Sep.
Article em En | MEDLINE | ID: mdl-18565574
OBJECTIVES: To describe the expression of vascular endothelial growth factor (VEGF), proto-oncogene macrophage colony-stimulating factor receptor (c-fms) and cyclooxygenase-2 (COX-2) in cervical carcinogenesis and to analyze the correlation of VEGF with c-fms and COX-2 expression. METHODS: In this study, 26 cases of benign cervix, 28 low-grade cervical intraepithelial neoplasia (CIN; CIN 1), 30 high-grade CIN (CIN 2/3) and 28 squamous cervical carcinomas (SCC) were examined by immunohistochemistry (IHC) and analysis was performed separately for epithelium and stroma. RESULTS: Positive epithelial expressions in normal cervix, low-grade CIN, high-grade CIN and SCC were, respectively: VEGF - 11.5%, 39.3%, 53.3% and 75% (P<0.001); c-fms - 0%, 10.7%, 40% and 67.9% (P<0.001); COX-2 - 7.7%, 39.3%, 80% and 100% (P<0.001). Stromal VEGF expression was higher than epithelial expression in all CIN grades and was also associated with the lesion grade, while c-fms and COX-2 stromal expression was weak. VEGF expression was statistically correlated to c-fms and COX-2 expression in high-grade CIN (P=0.020 and P=0.027, respectively) and SCC (P=0.015 and P=0.005, respectively). CONCLUSIONS: On the basis of our findings, these factors may participate in the development and progression of CIN lesions, with possible interaction of c-fms and COX-2 on VEGF expression, and may be potential molecular targets for studies of cervical cancer prevention and treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Receptor de Fator Estimulador de Colônias de Macrófagos / Fator A de Crescimento do Endotélio Vascular / Ciclo-Oxigenase 2 Limite: Female / Humans Idioma: En Revista: Gynecol Oncol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Receptor de Fator Estimulador de Colônias de Macrófagos / Fator A de Crescimento do Endotélio Vascular / Ciclo-Oxigenase 2 Limite: Female / Humans Idioma: En Revista: Gynecol Oncol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos