Histological and molecular temporomandibular joint analyses after mandibular advancement surgery: study in minipigs.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
; 106(3): 331-8, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18554945
OBJECTIVES: The objective of this study was to elucidate the changes occurring in the temporomandibular joint (TMJ) after surgical mandibular advancement with different fixation techniques: bicortical screws (rigid fixation) and miniplates (semi-rigid fixation). STUDY DESIGN: Eighteen minipigs were equally and randomly divided into 3 groups: Group I (control), nonoperated animals; Group II, animals submitted to surgical advancement surgery and osteosynthesis by bicortical screws; and Group III, animals submitted to surgical advancement surgery and osteosynthesis by miniplates. Four months after the surgeries, the presence of interleukin (IL)-6 and IL-10 in synovial fluid samples was assessed in ELISA experiments. TMJs were histologically prepared. RESULTS: Higher levels of IL-10 (P = .0436) were found for Group II. Descriptive histological analysis was compatible with the ELISA findings. CONCLUSIONS: Rigid fixation evokes more pronounced signs of bone remodeling in the TMJ, whereas malleable fixation promotes a more intense inflammatory activity. Therefore, rigid fixation seems to transmit a higher impact of postoperative masticatory forces to the TMJ.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Articulação Temporomandibular
/
Técnicas de Fixação da Arcada Osseodentária
/
Avanço Mandibular
/
Mandíbula
Limite:
Animals
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos