Graves' disease in Brazilian children and adults: lack of genetic association with CTLA-4 +49A>G polymorphism.
Horm Res
; 70(1): 36-41, 2008.
Article
em En
| MEDLINE
| ID: mdl-18493148
BACKGROUND/AIM: In several populations, major histocompatibility complex and CTLA-4 (cytotoxic T lymphocyte antigen-4) gene polymorphisms are related to adult subjects with Graves' disease (GD). Our aim was to study the association of +49A>G polymorphism of the CTLA-4 gene in Brazilian children and adults with GD and its correlation with clinical and laboratory markers of disease severity. METHODS: CTLA-4 +49A>G polymorphism was established by polymerase chain reaction-restriction fragment length polymorphism analysis in 44 children and 72 adults with GD and compared to a stringent control group consisting of octogenarians with no history of thyroid disease; free T4 and T3 levels and T3/T4 ratio, antithyroid antibodies, and Graves' ophthalmopathy were also evaluated according to genotype. RESULTS: No significant difference was found in the frequency of CTLA-4 +49A>G polymorphism among children and adults with GD compared to controls and within groups. There was no significant correlation between the presence of G allele and Graves' ophthalmopathy, gender, age at diagnosis, and biochemical markers of disease severity. CONCLUSION: The frequency of CTLA-4 +49A>G polymorphism is not different in children and adults with GD compared to the normal control population and does not seem to contribute independently to the severity of the clinical presentation of GD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos CD
/
Doença de Graves
/
Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Horm Res
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Suíça