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Neuroprotective effects of diltiazem in rabbits with occluded aorta.
Saba, Tonguc; Manduz, Sinasi; Sapmaz, Ismail; Tunel, Ali; Aker, Handan; Dogan, Kasim.
Afiliação
  • Saba T; Trabalho realizado na Cumhuriyet Universitesi, Turkey
Rev Bras Cir Cardiovasc ; 22(4): 416-24, 2007.
Article em En | MEDLINE | ID: mdl-18488108
OBJECTIVE: In the present study, we aimed to determine the protective effect of the perfusion of the distal aorta with diltiazem and ringer lactate solution on the spinal cord. METHODS: Twenty-seven New Zealand rabbits were used in which spinal cord ischemia was provided by occlusion of the aorta for thirty minutes. Experimental animals were divided into four groups: group A (n=4), the sham operation group; group B (n=8) in which intraaortic balloon occlusion alone was applied; group C (n=7), ringer lactate group in which ringer lactate was perfused into distal aorta at a rate of 40 ml/kg, hr, following intraaortic balloon occlusion; group D (n=8) diltiazem group in which diltiazem 40 mg/kg, hr, in Ringer lactate was perfused into distal aorta following intraaortic balloon occlusion. Motor function of hind limbs was evaluated by Tarlov's scoring system. After observation, spinal cords were removed for histopathological evaluation. RESULTS: The degree of histopathological injury was well correlated with neurological function. The most severe histopathological injury and neurological dysfunction occurred in group B, followed by group C, D and A respectively. No injury or neurological dysfunction occurred in the sham group. CONCLUSIONS: The protective effect of diltiazem on both histopathological injury and neurological function was significant in comparison with control groups.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta / Medula Espinal / Bloqueadores dos Canais de Cálcio / Diltiazem / Fármacos Neuroprotetores / Soluções Isotônicas Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Rev Bras Cir Cardiovasc Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta / Medula Espinal / Bloqueadores dos Canais de Cálcio / Diltiazem / Fármacos Neuroprotetores / Soluções Isotônicas Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Rev Bras Cir Cardiovasc Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil