Inflammatory aspects of depression.
Inflamm Allergy Drug Targets
; 7(1): 19-23, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18473896
A bidirectional relation between depression and natural immunity has been identified: depressive episodes are associated to a relative immunodeficiency, conversely inflammatory activity has been implicated in the development of depressive symptoms and in the pathophysiology of depression. Depression has been associated with a decrease in the number and activity of NK lymphocytes and hence patients with depression may show immunodeficiency towards intracellular microorganisms and tumors. Paradoxically, depression is sometimes accompanied by an inflammatory state, developed from the peripheral stimuli (atopy) or central stimuli (chronic stress) and mediated by proinflammatory cytokines (IL-6, TNF and IL-1). These cytokines can play a role in the pathophysiology of depression and of various diseases, supporting the hypothesis that many chronic diseases are individual manifestations of a common proinflammatory denominator.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Depressão
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Inflamm Allergy Drug Targets
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Emirados Árabes Unidos