[Prevalence of hemoglobin S in the State of Paraná, Brazil, based on neonatal screening]. / Prevalência da hemoglobina S no Estado do Paraná, Brasil, obtida pela triagem neonatal.
Cad Saude Publica
; 24(5): 993-1000, 2008 May.
Article
em Pt
| MEDLINE
| ID: mdl-18461228
The Brazilian Ministry of Health created the National Neonatal Screening Program under ruling no. 822/2001, including neonatal screening for hemoglobinopathies. In the State of Paraná, neonatal screening is conducted by the Ecumenical Foundation for the Protection of the Handicapped. The prevalence rates were determined for homozygous and heterozygous hemoglobin S and Sbeta-thalassemia. Blood samples drawn on filter paper were examined by isoelectric focusing (IEF) and high-performance liquid chromatography (HPLC). From January 2002 to December 2004, 548,810 newborns were screened, with the detection of 21 with FS, two FSA/FS, and four FSA. After confirmatory tests at six months of age, 12 were defined as sickle-cell anemia, or a prevalence of 2.2:100,000 newborns; Sbeta-thalassemia was confirmed in 15 (2.7:100,000 newborns); and 8,321 newborns were diagnosed as heterozygous HbS (1,500:100,000 newborns). HbS prevalence in Paraná (in southern Brazil) is lower than in the Central-West, North, and Northeast of the country. Ethnic origin of the population, fetal deaths, and non-random procreation may contribute to the relatively low number of homozygous individuals in the State. Sbeta-thalassemia interaction suggests the presence of Euro-Mediterranean peoples in this population's miscegenation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anemia Falciforme
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Screening_studies
Limite:
Humans
/
Newborn
País/Região como assunto:
America do sul
/
Brasil
Idioma:
Pt
Revista:
Cad Saude Publica
Assunto da revista:
SAUDE PUBLICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil