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GSTT1, GSTM1 and GSTP1 polymorphisms and susceptibility to juvenile idiopathic arthritis.
Rohr, P; Veit, T D; Scheibel, I; Xavier, R M; Brenol, J C T; Chies, J A B; Kvitko, K.
Afiliação
  • Rohr P; Departamento de Genética e Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
Clin Exp Rheumatol ; 26(1): 151-5, 2008.
Article em En | MEDLINE | ID: mdl-18328165
OBJECTIVE: In this study we have analyzed GSTM1, GSTT1 and GSTP1 polymorphisms in patients with juvenile idiopathic arthritis (JIA), to investigate a possible role of these genes as genetic components of the disease. METHODS: A total of 103 individuals (49 oligoarticular, 41 polyarticular and 13 systemic) were analyzed for the three polymorphisms, using a PCR/RFLP methodology. RESULTS: We have observed significantly increased frequencies of individuals with GSTT1 null genotype in JIA patients comparing to controls (37% x 21%; p=0.0183). There was a 2-fold increased risk (OR 2.2, 95% CI 1.2-4.1) associating the disease with the GSTT1 null genotype. Considering the subgroups (oligoarticular, polyarticular and systemic), the results indicated an association between polyarticular and systemic patients and the GSTT1 null genotype. There was a 2-fold increased risk for polyarticular patients (OR 2.4, 95%, CI 1.1-5.4), and a 4-fold increased risk for systemic patients (OR 4.4, 95%, 1.3-14.5). CONCLUSION: The GSTT1 null genotype seems to be involved in polyarticular and systemic JIA.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Juvenil / Suscetibilidade a Doenças / Glutationa S-Transferase pi / Glutationa Transferase Limite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Clin Exp Rheumatol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Itália
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Juvenil / Suscetibilidade a Doenças / Glutationa S-Transferase pi / Glutationa Transferase Limite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Clin Exp Rheumatol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Itália