The role of the NFkappaB signalling pathway in cancer.
Clin Transl Oncol
; 10(3): 143-7, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18321816
The nuclear factor kappa B (NFkappaB) signalling pathway regulates the expression of hundreds of genes that are involved in different cellular processes such as cell proliferation, survival, stress responses, cellular immunity and inflammation. Its aberrant regulation is involved in several pathologies, but its relevance in cellular transformation and cancer development has been extensively studied. Mutations in the core components of NFkappaB as well as in the cellular machinery that regulates its activation have been found in many types of tumours. On the other hand, its role in promoting cell survival is an important obstacle in many cancer therapies. The development of chemical inhibitors that block NFkappaB activation acting either directly on IKKs or on the proteosome machinery has shown antitumour and proapoptotic activity both in preclinical and clinical studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
NF-kappa B
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Clin Transl Oncol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Espanha
País de publicação:
Itália