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Disruption of mitochondrial function as the basis of the trypanocidal effect of trifluoperazine on Trypanosoma cruzi.
Lacuara, J L; de Barioglio, S R; de Oliva, P P; Bernacchi, A S; de Culasso, A F; Castro, J A; Franke de Cazzulo, B M; Cazzulo, J J.
Afiliação
  • Lacuara JL; Instituto de Fisiologia, Facultad de Ciencias Medicas, Universidad Nacional de Córdoba, Argentina.
Experientia ; 47(6): 612-6, 1991 Jun 15.
Article em En | MEDLINE | ID: mdl-1829686
The tricyclic anti-calmodulin drug trifluoperazine (TFP) inhibited growth and motility of epimastigotes of Trypanosoma cruzi, at concentrations lower than 100 microM, and motility and infectivity of the bloodstream trypomastigote form at 200 microM. Electron microscopy of TFP-treated epimastigotes showed that the major effect was at the mitochondrial level, with gross swelling and disorganization. The oligomycin-sensitive, mitochondrial ATPase was completely inhibited by 20 microM TFP, and the same drug concentration caused a 60% decrease in intracellular ATP content. The results suggest that the trypanocidal effect of TFP may be related more to mitochondrial damage than to the well-known anticalmodulin effect of the drug.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trifluoperazina / Tripanossomicidas / Trypanosoma cruzi / Mitocôndrias Limite: Animals Idioma: En Revista: Experientia Ano de publicação: 1991 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trifluoperazina / Tripanossomicidas / Trypanosoma cruzi / Mitocôndrias Limite: Animals Idioma: En Revista: Experientia Ano de publicação: 1991 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça