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Effect of L-5-Hydroxytryptophan on drinking behavior in Coturnix japonica (Temminck and Schlegel, 1849) (Galliformes: Aves): involvement of renin-angiotensin system.
Cedraz-Mercez, P L; Almeida, A C; Thomaz, C M; Costa-e-Sousa, R H; Olivares, E L; Côrtes, W S; Medeiros, M A; Reis, L C.
Afiliação
  • Cedraz-Mercez PL; Departamento de Ciências Fisiológicas, Instituto de Biologia, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 23890-000, Brazil.
Braz J Biol ; 67(4): 771-6, 2007 Nov.
Article em En | MEDLINE | ID: mdl-18278334
The purpose of this study was to explore the role of L-5-hydroxytryptophan (L-HTP) and its relationship with the renin-angiotensin system (RAS) on the drinking behavior in Japanese quails. Normally-hydrated quails that received injections of L-HTP (12.5; 25 and 50 mg.kg-1) by the intracoelomic route (ic) expressed an increase in water intake, which was inhibited by captopril, an angiotensin converting enzyme (ACE) inhibitor. In addition, captopril also induced such a response in birds under previous fluid deprivation. High doses of captopril (35-70 mg.kg-1, sc) in normally-hydrated quails decreased the spontaneous water intake while low doses of captopril (2-5 mg.kg-1, sc) did not prompt water intake after L-HTP administration. Losartan, an AT1 receptor antagonist in mammals, did not change the water intake levels in normally-hydrated or water-deprivated birds. Serotonin (5-HT) injections did not provoke its known dipsogenic response.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Renina-Angiotensina / 5-Hidroxitriptofano / Coturnix / Comportamento de Ingestão de Líquido Limite: Animals Idioma: En Revista: Braz J Biol Assunto da revista: BIOLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Renina-Angiotensina / 5-Hidroxitriptofano / Coturnix / Comportamento de Ingestão de Líquido Limite: Animals Idioma: En Revista: Braz J Biol Assunto da revista: BIOLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil