[Ocular toxicity due to 4-aminoquinoline derivatives]. / Toxicidade ocular por derivados da 4-aminoquinolona.
Arq Bras Oftalmol
; 70(6): 1046-51, 2007.
Article
em Pt
| MEDLINE
| ID: mdl-18235926
Retinal toxicity of chloroquine has been extensively studied since its first description in 1957. This drug is used on a chronic basis to treat several rheumatologic and dermatologic diseases, a there is a trend to use hydroxychloroquine rather than chloroquine. The recommended dose for hydroxychloroquine is 4 mg/kg lean body weight per day. The clinical picture of chloroquine retinopathy is characterized by a paracentral visual field scotoma with associated parafoveal retinal pigment epithelium atrophy, known as 'bull's eye maculopathy. The visual field and Amsler grids are the exams that early detect toxicity retinopathy. The authors aim to review the pathogenesis, clinical features, differential diagnosis, complementary exams, and treatment. The sources of references were PubMed (MEDLINE), LILACS and Ophthalmology Library databases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Retinianas
/
Doenças da Córnea
/
Aminoquinolinas
/
Antimaláricos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Pt
Revista:
Arq Bras Oftalmol
Ano de publicação:
2007
Tipo de documento:
Article
País de publicação:
Brasil