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Genetic alterations in juvenile nasopharyngeal angiofibromas.
Coutinho-Camillo, Cláudia M; Brentani, M Mitzi; Nagai, Maria A.
Afiliação
  • Coutinho-Camillo CM; Disciplina de Oncologia, Laboratório de Oncologia Experimental-24, Departamento de Radiologia da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Head Neck ; 30(3): 390-400, 2008 Mar.
Article em En | MEDLINE | ID: mdl-18228521
Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm of the nasopharynx that accounts for 0.5% of all head and neck tumors. Although histologically benign in appearance, JNAs are locally aggressive and destructive, spreading from the nasal cavity to the nasopharynx, paranasal sinuses, and orbit skull base with intracranial extension. The gender selectivity of JNA and the relatively young age at diagnosis suggest hormone-dependent development. Hormonal disorders have been reported in patients with JNA, and androgen and estrogen receptors have been identified in tumor tissue; however, a hormonal influence on JNA is controversial. Recent studies have attempted to further delineate the pathogenesis of JNA through analysis of genetic and molecular changes. Understanding of the molecular mechanisms involved in JNA might improve prevention, prognosis, and treatment of this tumor. In this review, we discuss published studies addressing the possible molecular pathways that might be involved in the development of JNA.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas / Angiofibroma Tipo de estudo: Prognostic_studies Limite: Child / Humans Idioma: En Revista: Head Neck Assunto da revista: NEOPLASIAS Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas / Angiofibroma Tipo de estudo: Prognostic_studies Limite: Child / Humans Idioma: En Revista: Head Neck Assunto da revista: NEOPLASIAS Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos