[Antinociceptive effects of the combination metamizol + morphine in rats with intense pain (arthritic gout-type pain produced with AU)]. / Efectos antinociceptivos de la combinación metamizol+morfina en ratas con dolor intenso (artritis de tipo "gota" producida por ácido úrico).
Cir Cir
; 75(5): 371-6, 2007.
Article
em Es
| MEDLINE
| ID: mdl-18158884
BACKGROUND: The antinociceptive effects of metamizol and morphine administered either separately or in combination were determined in the "Pain-Induced Functional Impairment Model in the Rat" (PIFIR antinociceptive model). METHODS: Intense nociception (or intense pain) was induced by the intra-articular injection of uric acid (50%) in the right hind limb inducing its dysfunction. Animals then received analgesic agents, and the recovery of functionality over time was assessed as an expression of antinociception. RESULTS: Metamizol (177.8 mg/kg s.c.) or morphine (3.2 mg/kg s.c.) separately resulted in a lower antinociceptive effect (22.1+/-5.4 area units [au] and 31.8+/-9.4 au, respectively). Moreover, the combination of metamizol (177.8 mg/kg) with morphine (3.2 mg/kg) resulted in a potentiation (293.7+/-16.6 au). The antinociceptive effect observed using the combination was significantly greater than expected on the basis of addition of the individual effects. The percent change in antinociceptive effects, using the combination, was 444.9%. CONCLUSIONS: This represents the first study to show that metamizol + morphine can produce potentiation of their antinociceptive effects in intense pain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Anti-Inflamatórios não Esteroides
/
Dipirona
/
Analgésicos Opioides
/
Morfina
Limite:
Animals
Idioma:
Es
Revista:
Cir Cir
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
México