Your browser doesn't support javascript.
loading
Effects of an acute treatment with L-thyroxine on memory, habituation, danger avoidance, and on Na+, K+ -ATPase activity in rat brain.
dos Reis-Lunardelli, Eleonora Araújo; Ramirez, Maria Rosana; Castro, Cibele Canal; Coitinho, Adriana Simon; Bavaresco, Caren; da Trindade, Laura Schumacher Schuh; Perrenoud, Myriam Fortes; Wyse, Angela Terezinha de Souza; Sarkis, João José Freitas; Izquierdo, Iván.
Afiliação
  • dos Reis-Lunardelli EA; Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. reis.lunardelli@gmail.com
Curr Neurovasc Res ; 4(4): 259-67, 2007 Nov.
Article em En | MEDLINE | ID: mdl-18045151
Thyroid hormones (THs) have a relevant action on brain development and maintenance. By using an acute treatment to induce a hyperthyroid animal model, we aimed at investigating the effect of an altered THs levels on learning and memory and on the activity of Na(+), K(+)-ATPase in the rat brain. Our results have shown that the acute treatment with L-T4 did not alter the retrieval of the inhibitory avoidance task, but had a significant effect on the elevated plus maze and on open-field performance in rats. We suggest that animals subjected to L-T4 administration improved the habituation to a novel environment as well as a better evaluation of a dangerous environment, respectively. Na(+), K(+)-ATPase activity is increased in parietal cortex (30%), but it is not altered in hippocampus in L-T4 treated group. These both brain structures are involved in memory processing and it was previously demonstrated that there is a double dissociation between them for spatial location information, perceptual and episodic memory. We propose the hypothesis that this increase of Na(+), K(+)-ATPase activity in parietal cortex may be correlated to our results in behavior tests, which suggest a role of THs as well as of the Na(+), K(+)-ATPase in the cognitive process.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Assunção de Riscos / Tiroxina / Comportamento Animal / Encéfalo / ATPase Trocadora de Sódio-Potássio / Habituação Psicofisiológica / Memória Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Curr Neurovasc Res Assunto da revista: ANGIOLOGIA / NEUROLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Assunção de Riscos / Tiroxina / Comportamento Animal / Encéfalo / ATPase Trocadora de Sódio-Potássio / Habituação Psicofisiológica / Memória Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Curr Neurovasc Res Assunto da revista: ANGIOLOGIA / NEUROLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos