Argemone mexicana decoction for the treatment of uncomplicated falciparum malaria.
Trans R Soc Trop Med Hyg
; 101(12): 1190-8, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-17920092
A prospective, dose-escalating, quasi-experimental clinical trial was conducted with a traditional healer using a decoction of Argemone mexicana for the treatment of malaria in Mali. The remedy was prescribed in three regimens: once daily for 3 days (Group A; n=23); twice daily for 7 days (Group B; n=40); and four times daily for the first 4 days followed by twice daily for 3 days (Group C; n=17). Thus, 80 patients were included, of whom 80% were aged<5 years and 25% were aged<1 year. All presented to the traditional healer with symptoms of malaria and had a Plasmodium falciparum parasitaemia>2000/microl but no signs of severe malaria. The proportions of adequate clinical response (ACR) at Day 14 were 35%, 73% and 65% in Groups A, B and C, respectively (P=0.011). At Day 14, overall proportions of ACR were lower in children aged<1 year (45%) and higher in patients aged>5 years (81%) (P=0.027). Very few patients had complete parasite clearance, but at Day 14, 67% of patients with ACR had a parasitaemia<2000/microl. No patient needed referral for severe disease. Only minor side effects were observed. Further research should determine whether this local resource could represent a first-aid home treatment in remote areas.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Malária Falciparum
/
Preparações de Plantas
/
Argemone
/
Fitoterapia
/
Antimaláricos
Tipo de estudo:
Observational_studies
Limite:
Animals
/
Child
/
Child, preschool
/
Humans
/
Infant
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Suíça
País de publicação:
Reino Unido