Stentless valves treated by the L-hydro process in the aortic position in sheep.
Asian Cardiovasc Thorac Ann
; 15(5): 413-7, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17911070
Calcification of glutaraldehyde-treated bioprosthetic heart valves is a major cause of long-term failure. We studied porcine aortic valves treated by the L-Hydro process and implanted into 14 juvenile sheep (group 1). Another 10 sheep were implanted with glutaraldehyde-treated porcine bioprostheses (group 2). The animals were sacrificed after 150 days and the explanted valves were analyzed for calcification. Hemodynamic measurements by echocardiography and angiography were carried out prior to sacrifice. Macroscopic analysis showed calcification and loss of mobility of the leaflets in all group 2 implants and in one group 1 implant. Light microscopy showed foci of calcification in all group 2 implants and in 3 valves from group 1. A significant reduction in the level of calcification was found in porcine bioprostheses treated by the L-Hydro process and implanted into the juvenile sheep model.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Valva Aórtica
/
Bioprótese
/
Calcinose
/
Próteses Valvulares Cardíacas
/
Fixação de Tecidos
/
Glutaral
/
Implante de Prótese de Valva Cardíaca
/
Fixadores
/
Doenças das Valvas Cardíacas
Limite:
Animals
Idioma:
En
Revista:
Asian Cardiovasc Thorac Ann
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido