Abnormal circadian blood pressure regulation in children born preterm.
J Pediatr
; 151(4): 399-403, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17889077
OBJECTIVE: To assess a possible relationship between prematurity and casual blood pressure (BP) by means of 24-hour ambulatory BP monitoring (ABPM). STUDY DESIGN: ABPM was performed in 41 children aged 5 to 17 years who were born prematurely with (n = 11) or without intrauterine growth restriction, and in 27 matched children who were born at term with a birth weight appropriate for gestational age. RESULTS: Although BP did not differ between the preterm group and control subjects during the daytime, nocturnal standardized systolic BP was elevated (P < .05) and a lack of nocturnal decrease was more prevalent in the preterm children compared with the control subjects (73% versus 41%, P = .01). The difference was caused by a marked increase of nighttime systolic BP in the light-for-date children (1.17 +/- 0.61 standard deviation scores; P < .01), although preterm children with appropriate weight (0.33 +/- 1.00) were not different from control subjects (0.09 +/- 0.73). Nighttime BP standard deviation scores were closely correlated with standardized heart rate, compatible with a role of sympathetic hyperactivation. CONCLUSION: Subtle abnormalities of BP regulation, indicated by a selective increase of nocturnal systolic BP, are present during childhood in subjects born prematurely, and are prominent in those with intrauterine growth restriction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Recém-Nascido Prematuro
/
Recém-Nascido Pequeno para a Idade Gestacional
/
Ritmo Circadiano
/
Retardo do Crescimento Fetal
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Newborn
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Turquia
País de publicação:
Estados Unidos