Analysis of C-850T and G-308A polymorphisms of the tumor necrosis factor-alpha gene in Maya-Mestizo women with preeclampsia.
Hypertens Pregnancy
; 26(3): 283-91, 2007.
Article
em En
| MEDLINE
| ID: mdl-17710577
OBJECTIVE: To determine whether polymorphisms in the TNF-alpha promoter gene are associated with preeclampsia. METHODS: 105 women with preeclampsia and 200 controls were genotyped for the G-308A and C-850T polymorphisms by RFLP. Differences in allele, genotype, and haplotype frequencies between groups were assessed. RESULTS: The genotypic and allelic distribution of both polymorphisms was similar between groups. Moreover, the estimated overall pair of loci haplotype frequencies did not differ significantly. CONCLUSION: We did not find any association between these polymorphisms and the risk for preeclampsia. However, we found that both the genotypic and allelic distribution in our population differed from those reported in other populations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Fator de Necrose Tumoral alfa
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Hypertens Pregnancy
Assunto da revista:
ANGIOLOGIA
/
OBSTETRICIA
Ano de publicação:
2007
Tipo de documento:
Article
País de publicação:
Reino Unido