[Usefulness of GH and IGF-1 to establish the dose and frequency of application of octreotide to treat acromegaly]. / IGF-1 y hormona de crecimiento. Marcadores para la aplicación de octreótida en acromegalia.
Rev Med Inst Mex Seguro Soc
; 45(3): 291-5, 2007.
Article
em Es
| MEDLINE
| ID: mdl-17692168
OBJECTIVE: to determine the dose and frequency of application of octreotide LAR to treat acromegaly by monitoring the levels of circulating growth hormone (GH) and insulin-like growth factor (IGF-1). MATERIAL AND METHODS: twelve patients (five men and seven women) with acromegaly, whose age was on average 48.9 years (range 35-67) participated. Eight had been surgically treated, yet non cured and 4 patients were treated de novo. The study lasted between 12-18 months. The initial octreotide dose was 20 mg/4 weeks intramuscular. Before administering the fourth dose, the levels of IGF-1 and GH were measured; then, the dose was adjusted and three more injections were applied. If the levels of GH and IGF-1 continued safe, the dose and frequency of application of octreotide LAR were individualized thus applying the minimum number of injections. RESULTS: the interval of octreotide LAR application to maintain the levels of GH and IGF-1 within safe range was prolonged to more than four weeks in nine patients (75%); in six patients (50%), the interval changed to eight weeks and to twelve weeks in three patients (25%). Three patients (25%) continued receiving injections in four-week intervals. The levels of GH and IGF-1 were lower during the treatment period when compared with the baseline measurements (p < 0.01). CONCLUSION: the adjustment of the dose of octreotide LAR keeps the levels of GH within safe range and reduces in 75% the frequency of injections to treat acromegaly.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acromegalia
/
Fator de Crescimento Insulin-Like I
/
Hormônio do Crescimento
/
Octreotida
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Rev Med Inst Mex Seguro Soc
Assunto da revista:
MEDICINA
/
MEDICINA SOCIAL
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
México