The adrenaline microinjection into the median raphe nucleus induced hypophagic effect in rats submitted to food restriction regimen.
Neurosci Lett
; 422(2): 123-7, 2007 Jul 11.
Article
em En
| MEDLINE
| ID: mdl-17630208
The effect of the equimolar doses (6, 20 and 60 nmol) of either adrenaline (AD) or noradrenaline (NA) microinjected into the median raphe nucleus (MR) on feeding behavior of food-restricted rats (15 g/day/rat) was investigated. The data indicated that 20 nmol AD microinjection, but not NA, into the MR decreased the animal food intake. This hypophagic effect induced by AD may be ascribed to a feeding bout conclusion (satiation process) and not to any changes in non-ingestive behaviors induced by drug microinjection. Since equimolar doses of NA failed to change the animal feeding behavior, it is possible to say that AD-induced hypophagia may be due to either changes in tonic stimulatory control exerted by endogenous noradrenaline on MR or to AD-beta(2) receptor activation in the MR. We claim that such activation may be much more importantly exerted by adrenaline-containing afferents to MR neurons involved with ingestive behavior than by noradrenergic inputs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apetite
/
Regulação do Apetite
/
Núcleos da Rafe
/
Epinefrina
/
Privação de Alimentos
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Irlanda