Your browser doesn't support javascript.
loading
Effects of bisoprolol on cardiac function and exercise in patients with heart failure.
Issa, Victor Sarli; Guimarães, Guilherme Vieira; Rezende, Marcos Valério Coimbra; Cruz, Fátima das Dores; Ferreira, Silvia Moreira Ayub; Bacal, Fernando; Bocchi, Edimar Alcides.
Afiliação
  • Issa VS; Instituto do Coração, FM, USP, São Paulo, SP, Brazil. victorissa@cardiol.br
Arq Bras Cardiol ; 88(3): 340-5, 2007 Mar.
Article em En, Pt | MEDLINE | ID: mdl-17533477
OBJECTIVE: To assess the effects of bisoprolol on exercise capacity and ventricular function in patients with heart failure. METHODS: Clinical and hemodynamic variables, ventricular function and remodeling, and ergospirometry of patients with heart failure of different etiologies were evaluated before and after the administration of bisoprolol. RESULTS: Twenty-two patients were analyzed; one patient did not tolerate medication and 14 patients reached the study goal. The group consisted of 9 men and 5 women, the mean age was 52 (36-64) years, and patients were followed during 551 days (238-1109). We observed an improvement in NYHA functional class, reduction in resting heart rate (78.8+/-8.7 vs 63+/-6.4 bpm, p <0.001), increase in left ventricular ejection fraction (31.3+/-8.5% vs 39+/-14.7%. p=0.043), and a tendency towards improved quality of life scores (31+/-20.6 vs 17.8+/-14.8. p=0.058). The maximum heart rate dropped during exercise (138.1+/-20.2 vs 116.7+/-27.1. p=0.01), as did peak oxygen consumption (20.9+/-6.8 vs 15.1+/-3.5. p<0.001); no change was observed on the EV/VCO2 slope. The effects were observed for all etiologies, including Chagas disease. CONCLUSION: Bisoprolol was safe and well tolerated in patients with heart failure. Bisoprolol therapy improved the symptoms, hemodynamic variables, as well as the cardiac function for all etiologies; however, it did not result in improved exercise capacity.
Assuntos
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Bisoprolol / Antagonistas Adrenérgicos beta / Insuficiência Cardíaca Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies Aspecto: Patient_preference Limite: Adult / Female / Humans / Male / Middle aged Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Bisoprolol / Antagonistas Adrenérgicos beta / Insuficiência Cardíaca Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies Aspecto: Patient_preference Limite: Adult / Female / Humans / Male / Middle aged Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil