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Cross-sectional observations of thyroid function in geriatric Mexican outpatients with and without dementia.
Cárdenas-Ibarra, Lilia; Solano-Velázquez, José A; Salinas-Martínez, Ricardo; Aspera-Ledezma, Thelma D; Sifuentes-Martínez, Macarena Del R; Villarreal-Pérez, Jesús Z.
Afiliação
  • Cárdenas-Ibarra L; Endocrinology Service, University Hospital, School of Medicine, Autonomous University of Nuevo León, Avenida Madero s/n y Gonzalitos, Colonia Mitras Centro, Monterrey 64460, Mexico. dralilia@gmail.com
Arch Gerontol Geriatr ; 46(2): 173-80, 2008.
Article em En | MEDLINE | ID: mdl-17512618
UNLABELLED: This work was aimed at determining and comparing the frequency of abnormal levels of thyroid stimulating hormone (TSH) in geriatric outpatients with and without dementia. This cross-sectional study enrolled patients, aged 60 years and older with or without dementia (established on the basis of DSM-IV-R), from geriatric outpatient unit with third level of medical care. Comparisons were between 33 (34%) patients without dementia versus 26 (58%) with dementia; both among 142 (24%) randomly selected sample (RSS) from unit's register; and the 101 (89%) in the memory-clinic case series (MCCS) of dementia were contrasted with the former. MEASUREMENTS: TSH, total/free thyroxine, mini-mental-state examination (MMSE), geriatric depression scale (GDS), Hachinski ischemic-score (HIS), and clinical data from the patients' charts. In the above order, high TSH was found in 9 (27.3%, confidence interval (CI)=12.1-42.5%), 6 (23.1%, CI=6.9-46.5%), and 30 (29.7%, CI=20.8-38.6%), respectively. Low-normal free thyroxine levels accompanied 76% of individuals with elevated TSH; in contrast of Gaussian distribution of free thyroxine in those with TSH in normal range. In conclusion, the high frequency found of hypothyroidism in patients with and without dementia warrants further studies. Treatment is only being recommended for patients with below range thyroxin levels; while treatment of subclinical hypothyroidism in the presence of cognitive decline will be addressed in the forthcoming studies.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pacientes Ambulatoriais / Glândula Tireoide / Tiroxina / Tireotropina / Americanos Mexicanos / Demência / Hipotireoidismo Tipo de estudo: Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Arch Gerontol Geriatr Ano de publicação: 2008 Tipo de documento: Article País de afiliação: México País de publicação: Holanda
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pacientes Ambulatoriais / Glândula Tireoide / Tiroxina / Tireotropina / Americanos Mexicanos / Demência / Hipotireoidismo Tipo de estudo: Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Arch Gerontol Geriatr Ano de publicação: 2008 Tipo de documento: Article País de afiliação: México País de publicação: Holanda