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Cyclosporine A inhibits acetylcholinesterase activity in rats experimentally demyelinated with ethidium bromide.
Mazzanti, Cinthia M; Spanevello, Roselia; Ahmed, Musthaq; Schmatz, Roberta; Mazzanti, Alexandre; Salbego, Fabiano Z; Graça, Dominguita L; Sallis, Eliza S V; Morsch, Vera M; Schetinger, Maria Rosa C.
Afiliação
  • Mazzanti CM; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcellos, 2600-Anexo, 90035-003 Porto Alegre, RS, Brazil.
Int J Dev Neurosci ; 25(4): 259-64, 2007 Jun.
Article em En | MEDLINE | ID: mdl-17467222
Cyclosporine A is the major immunosuppressive agent used for organ transplantation and for the treatment of a variety of autoimmune disorders such as multiple sclerosis. In this work, we investigated the effect of the cyclosporine A on the acetylcholinesterase activity in the cerebral cortex, striatum, hippocampus, hypothalamus, cerebellum and pons of the rats experimentally demyelinated by ethidium bromide. Rats were divided into four groups: I control (injected with saline), II (treated with cyclosporine A), III (injected with 0.1% ethidium bromide) and IV (injected with 0.1% the ethidium bromide and treated with cyclosporine A). The results showed a significant inhibition (p<0.05) of acetylcholinesterase activity in the groups II, III and IV in all brain structures analyzed. In the striatum, hippocampus, hypothalamus and pons the inhibition was greater (p<0.005) when ethidium bromide was associated with cyclosporine A. In conclusion, the present investigation demonstrated that cyclosporine A is an inhibitor of acetylcholinesterase activity and this effect is increased after an event of toxic demyelination of the central nervous system.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Doenças Desmielinizantes / Ciclosporina / Antirreumáticos Limite: Animals Idioma: En Revista: Int J Dev Neurosci Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Doenças Desmielinizantes / Ciclosporina / Antirreumáticos Limite: Animals Idioma: En Revista: Int J Dev Neurosci Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos