[Antineutrophil cytoplasmic antibody (Anca)-associated autoimmune disease induced by propylthiouracil]. / Auto-imunidade ANCA (Anticorpo Anti-Citoplasma de Neutrófilos) positiva induzida por propiltiouracil: relato de caso e revisão da literatura.
Arq Bras Endocrinol Metabol
; 51(1): 136-41, 2007 Feb.
Article
em Pt
| MEDLINE
| ID: mdl-17435868
Antithyroid drugs sometimes cause severe complications. Propylthiouracil (PTU) can be associated to ANCA positive vasculitis, most often related to myeloperoxidase subtype (ANCA-MPO). Our objective is to describe a female patient with Graves' disease, who developed PTU induced-autoimmune disease, with cutaneous, pulmonary, and renal lesions, associated with ANCA. Histopathological examination revealed diffuse pulmonary hemorrhage, and focal segmental glomerulosclerosis at the kidney biopsy. She was treated with systemic corticosteroid therapy and cyclophosphamide, with clinical improvement. This case highlights the need for greater awareness of this relatively rare adverse effect of propylthiouracil.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propiltiouracila
/
Doenças Autoimunes
/
Antitireóideos
/
Vasculite
/
Peroxidase
/
Anticorpos Anticitoplasma de Neutrófilos
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
Pt
Revista:
Arq Bras Endocrinol Metabol
Ano de publicação:
2007
Tipo de documento:
Article
País de publicação:
Brasil