[Serum levels of interferon-gamma and interleukine-10 in anemic children with vitamin A deficiency]. / Interferón-gamma e interleucina-l0 sérica en niños anémicos con deficiencia de vitamina A.
Arch Latinoam Nutr
; 56(4): 329-34, 2006 Dec.
Article
em Es
| MEDLINE
| ID: mdl-17425177
Studies done with human and animals have shown that the diminished vitamin A intake can produce anemia, but the ethiopathogenic mechanism hasn't been known due to the few studies about the complex interactions between micronutrients deficiencies, immune system and cytokine productions. The objective of the present study was to analyze the serum concentration of IFN-gamma and IL-10 in anemic and non anemic children according to vitamin A nutritional status. A descriptive study of 53 euthrophic children, without infectious diseases (45-77 month old; 29 girls, 24 boys), living in a slum in Maracaibo-Venezuela. Anemia was evaluated by means of blood hemoglobin concentration analysis, standard WHO criteria for anemia were Hb < 110 g/L in <60 month old children; Hb < 115 g/L in >60 month old children. Vitamin A status was assessed by Conjunctival Impression Cytology (CIC) technique, which determines Normal CIC=Control or Abnormal CIC=VAD. The serum concentration of IFN-gamma and IL-10 (pg/mL; X +/- DE), was determined by the ELISA method. Statistical significance of differences was tested by ANOVA (p < 0.05). Prevalence of anemia was 75.50%; VAD 50.94% and anemia+VAD 35.86%. The anemic children with VAD showed significant serum values of IFN-gamma e IL-10 lower than in other groups. This alteration of the complex immunoregulatory mechanism could be responsible for dysfunction eritrhoid cell formation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina A
/
Estado Nutricional
/
Interferon gama
/
Interleucina-10
/
Anemia Ferropriva
Tipo de estudo:
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Venezuela
Idioma:
Es
Revista:
Arch Latinoam Nutr
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Venezuela