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[Contributions of pharmacogenomics to enhance the efficiency of randomized clinical trials]. / Aspectos metodológicos y éticos de la farmacogenómica en los ensayos clínicos aleatorizados.
de Jesús Castillejos-López, Manuel; García-Sancho, Maria Cecilia; Torres-Espíndola, Luz Maria; Pérez-Padilla, José Rogelio.
Afiliação
  • de Jesús Castillejos-López M; Instituto Nacional de Enfermedades Respiratorias.
Rev Invest Clin ; 58(5): 512-24, 2006.
Article em Es | MEDLINE | ID: mdl-17408112
One of the greatest advances of the modern medicine has been the report of the complete sequence of the human genome. This has brought as a consequence an evolution in the design of the clinical research, in special of the randomized clinical trials (RCTs). The pharmacogenomics, a powerful tool for the prediction of pharmacological effects based on the genotype of the studied subjects, promises to be very useful next years for the development of the pharmaceutical industry. With the present integration of the pharmacogenomical methods to the investigation and development of new medicines it may start a new era in the medical prescription producing more individualized therapies, reduction of adverse events in the patients and in addition a faster development of new medicines in a more cost-effective way. Nevertheless new methodological, ethical and social challenges appear that will have to be solved simultaneously, to allow a legal use of the vast information generated by the genetic information.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética / Ensaios Clínicos Controlados Aleatórios como Assunto Tipo de estudo: Clinical_trials / Prognostic_studies Aspecto: Ethics Limite: Humans Idioma: Es Revista: Rev Invest Clin Assunto da revista: MEDICINA Ano de publicação: 2006 Tipo de documento: Article País de publicação: México
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética / Ensaios Clínicos Controlados Aleatórios como Assunto Tipo de estudo: Clinical_trials / Prognostic_studies Aspecto: Ethics Limite: Humans Idioma: Es Revista: Rev Invest Clin Assunto da revista: MEDICINA Ano de publicação: 2006 Tipo de documento: Article País de publicação: México