Antigiardial activity of triterpenoids from root bark of Hippocratea excelsa.
J Nat Prod
; 70(5): 863-5, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17385912
Two new triterpenoids, 21 beta-hydroxyolean-12-en-3-one (1) and a seco-dinor derivative of pristimerine named dzununcanone (2), were isolated from the root bark of Hippocratea excelsa. Their structures were assigned on the basis of spectroscopic evidence, mainly 1H and 13C 1D and 2D NMR including DEPT, COSY, ROESY, HSQC, and HMBC experiments, as well as EIMS and HREIMS. The known 21alpha-hydroxy-3-oxofriedelane (3), a compound new to the species, and the known methide quinones pristimerine (4) tingenone (5), and xuxuarine Ebeta (7) were also isolated. The antiprotozoal activities were determined against Giardia intestinalis. Pristimerine and tingenone were the most active antigiardial compounds, with IC50 values of 0.11 and 0.74 microM, respectively, compared with metronidazole, the current drug of choice (IC50 1.23 microM).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Triterpenos
/
Giardia lamblia
/
Hippocrateaceae
/
Antiprotozoários
Limite:
Animals
País/Região como assunto:
Mexico
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2007
Tipo de documento:
Article
País de publicação:
Estados Unidos