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Genotypes of the mannan-binding lectin gene and susceptibility to visceral leishmaniasis and clinical complications.
Alonso, Diego Peres; Ferreira, Afonso Flávio B; Ribolla, Paulo Eduardo M; de Miranda Santos, Isabel K F; do Socorro Pires e Cruz, Maria; Aécio de Carvalho, Fernando; Abatepaulo, Antonio Roberto R; Lamounier Costa, Dorcas; Werneck, Guilherme L; Farias, Teresinha J C; Soares, Maria José S; Costa, Carlos Henrique N.
Afiliação
  • Alonso DP; Department of Parasitology, Institute for Biology and Biomedicine, São Paulo State University, Botucatu, Brazil.
J Infect Dis ; 195(8): 1212-7, 2007 Apr 15.
Article em En | MEDLINE | ID: mdl-17357060
BACKGROUND: Visceral leishmaniasis (VL) is almost always lethal if not treated, but most infections with the causative agents are clinically silent. Mannan-binding lectin (MBL), an opsonin, is a candidate molecule for modifying progression to VL because it may enhance infection with intracellular pathogens. Mutations in the MBL2 gene decrease levels of MBL and may protect against development of VL. This case-control study examines genotypes of MBL2 and levels of MBL in individuals presenting with different outcomes of infection with Leishmania chagasi. METHODS: Genotypes for MBL2 and levels of serum MBL were determined in uninfected control subjects (n=76) and in individuals presenting with asymptomatic infection (n=90) or VL (n=69). RESULTS: Genotypes resulting in high levels of MBL were more frequent (odds ratio [OR], 2.5 [95% confidence interval [CI], 1.3-5.0]; P=.006) among individuals with VL than among those with asymptomatic infections and were even more frequent (OR, 3.97 [95% CI, 1.10-14.38]; P=.043) among cases of VL presenting with clinical complications than among those with uneventful courses. Serum levels of MBL were higher (P=.011) in individuals with VL than in asymptomatic infections . CONCLUSIONS: Genotypes of the MBL2 gene predict the risk for developing VL and clinical complications in infections with L. chagasi.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmania infantum / Lectina de Ligação a Manose / Leishmaniose Visceral Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Infect Dis Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmania infantum / Lectina de Ligação a Manose / Leishmaniose Visceral Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Infect Dis Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos