Effects of hypertension on abdominal wall healing: experimental study in rats.
Surg Today
; 37(3): 215-9, 2007.
Article
em En
| MEDLINE
| ID: mdl-17342360
PURPOSE: The aim of this study was to investigate the effects of untreated and treated hypertension on abdominal wall healing. METHODS: Thirty-two spontaneously hypertensive rats (SHR) were randomly allocated into two groups: H (n = 16), untreated and E (n = 16), treated with enalapril (40 mg/kg per day). Group C (n = 16) was a nonhypertensive control group. The animals of each group were submitted to a midline laparotomy and randomly divided, according to the day on which they were killed (7th or 14th postoperative day), into subgroups of 8 animals, as follows: H-7, H-14, E-7, E-14, C-7 and C-14. On the day of their deaths, two strips of the anterior abdominal wall were collected. One strip was submitted to breaking strength measurement and the other to hydroxyproline determination. RESULTS: No mortalities or complications were observed in the six subgroups. The breaking strength in E-7 subgroup was significantly lower than in C-7 (P < 0.05). The tissue hydroxyproline levels were similar in all six subgroups (P > 0.05). CONCLUSIONS: Untreated hypertension had no effect on the abdominal wall healing of rats. Hypertensive animals treated with enalapril showed a significant decrease in abdominal wound-breaking strength on the 7th postoperative day.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Enalapril
/
Parede Abdominal
/
Hipertensão
/
Anti-Hipertensivos
Limite:
Animals
Idioma:
En
Revista:
Surg Today
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Japão