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Short allele of serotonin transporter gene promoter is a risk factor for obesity in adolescents.
Sookoian, Silvia; Gemma, Carolina; García, Silvia I; Gianotti, Tomas Fernández; Dieuzeide, Guillermo; Roussos, Adriana; Tonietti, Miriam; Trifone, Liliana; Kanevsky, Diego; González, Claudio D; Pirola, Carlos J.
Afiliação
  • Sookoian S; Molecular Cardiology, Institute of Medical Research, A Lanari, University of Buenos Aires, Buenos Aires, Argentina.
Obesity (Silver Spring) ; 15(2): 271-6, 2007 Feb.
Article em En | MEDLINE | ID: mdl-17299098
Obesity and hypertension are increasing medical problems in adolescents. Serotonin transporter (5-HTT) is involved in mood and eating disturbances. Encoded by the gene SLC6A4, the promoter shows functional insertion/deletion alleles: long (L) and short (S). Because individuals who are carriers for the short version are known to be at risk for higher levels of anxiety, we hypothesized that this variant may be associated with overweight. Data and blood samples were collected from 172 adolescents out of a cross-sectional, population-based study of 934 high school students. To replicate the findings, we also included 119 outpatients from the Nutrition and Diabetes Section of the Children's County Hospital. We found that the S allele was associated with overweight (BMI > 85th percentile), being a risk factor for overweight independently of sex, age, and hypertension [odds ratio (OR): 1.85; 95% confidence interval (CI): 1.13, 3.05; p < 0.02]. Additionally, in the outpatient study, compared with the homozygous LL subjects, S allele carriers showed a higher BMI z-score (1.47 +/- 1.09 vs. 0.51 +/- 1.4; p < 0.002) and were more frequent in overweight children. In conclusion, the S allele of the SLC6A4 promoter variant is associated with overweight being an independent genetic risk factor for obesity.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regiões Promotoras Genéticas / Proteínas da Membrana Plasmática de Transporte de Serotonina / Obesidade Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Obesity (Silver Spring) Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / METABOLISMO Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regiões Promotoras Genéticas / Proteínas da Membrana Plasmática de Transporte de Serotonina / Obesidade Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Obesity (Silver Spring) Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / METABOLISMO Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos