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p53 and p21WAF1/CIP1 overexpression at the invasive front of lower lip squamous cell carcinoma.
Horta, Martinho Campolina Rebello; de Assis, Luis Alpino Prandini; de Souza, Antonio Francisco; de Araújo, Vera Cavalcanti; Gomez, Ricardo Santiago; Aguiar, Maria Cássia Ferreira.
Afiliação
  • Horta MC; School of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, MG, Brazil. martinhohorta@pucminas.br
J Oral Pathol Med ; 36(2): 88-92, 2007 Feb.
Article em En | MEDLINE | ID: mdl-17238970
BACKGROUND: Lower lip squamous cell carcinoma (LLSCC) is an oral cancer that has distinct epidemiology and etiopathogenesis. Although risk factors for this neoplasia are acknowledged, few studies have investigated the molecular basis of its development and behavior. METHODS: Expression of p53 and p21(WAF1/CIP1) was examined by immunohistochemistry of archived tissue from 21 specimens of LLSCC. Differences in this expression between the whole tumor (WT) and the invasive front (IF) as well as correlation between p53 and p21(WAF1/CIP1) expression were analyzed. RESULTS: p53 and p21(WAF1/CIP1) were overexpressed at the IF of LLSCC. The expression of both proteins was higher at IF than at WT. No correlation was observed between p53 and p21(WAF1/CIP1) expression. CONCLUSIONS: Our results indicate that p53 and p21(WAF1/CIP1) overexpression is important in LLSCC pathogenesis, reinforce that IF is the most important area for tumor behavior, and support that p53-independent mechanisms should be involved in the expression of p21(WAF1/CIP1).
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Labiais / Carcinoma de Células Escamosas / Proteínas de Ligação a DNA / Inibidor de Quinase Dependente de Ciclina p21 Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Oral Pathol Med Assunto da revista: ODONTOLOGIA / PATOLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Labiais / Carcinoma de Células Escamosas / Proteínas de Ligação a DNA / Inibidor de Quinase Dependente de Ciclina p21 Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Oral Pathol Med Assunto da revista: ODONTOLOGIA / PATOLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca