Molecular biology of testicular germ cell tumors.
Clin Transl Oncol
; 8(12): 846-50, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17169757
Testicular germ cell tumors (TCGT) comprise a heterogeneous group of neoplasms, although all of them are originated from common precursors related to germ cell lineage. Understanding of normal development of germinal cells is essential to define new markers for diagnosis, prognostic subgroups and targeted therapies. Recent advances related to cytogenetic and molecular features have established the role of immunohistochemistry of c-kit, OCT-3/4 and determination of gain of chromosome 12 in the daily workup of premalignant lesions and invasive tumors. This review summarizes the current knowledge in the field of molecular biology of TGCT.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Testiculares
/
Biomarcadores Tumorais
/
Neoplasias Embrionárias de Células Germinativas
Limite:
Humans
/
Male
Idioma:
En
Revista:
Clin Transl Oncol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Espanha
País de publicação:
Itália