Your browser doesn't support javascript.
loading
Cytotoxic activity of orsellinates.
Gomes, Alcir T; Honda, Neli K; Roese, Fernanda M; Muzzi, Rozanna M; Sauer, Leandro.
Afiliação
  • Gomes AT; Universidade Federal de Mato Grosso do Sul, Departamento de Química, C. Postal 549, 79070-900, Campo Grande, Mato Grosso do Sul, Brazil.
Z Naturforsch C J Biosci ; 61(9-10): 653-7, 2006.
Article em En | MEDLINE | ID: mdl-17137109
The series of 2,4-dihydroxy-6-methylbenzoates 2-10 (methyl to hexyl orsellinates) prepared by alcoholysis of lecanoric acid (1)--a natural product from the lichen Parmotrema tinctorum (Nyl.) Hale - was submitted to the brine shrimp lethality test (BST), which was also performed for 2,4-dihydroxy-6-methylbenzoic acid (11) (orsellinic acid) and the derivative ethyl-2-hydroxy-4-methoxy-6-methylbenzoate (12) (4-methoxy-ethyl orsellinate), in order to detect new substances with probable antineoplasic activity. Results showed that chain elongation--increase in lipophilicity (log P)--causes a rise in the cytotoxic activity of orsellinates. Hexyl orsellinate (7) showed the highest cytotoxic activity (LC50 = 31 microM). A correlation between lipophilicity (log P) and cytotoxic activity (log 1/LC50) is presented. Compounds with ramified chains--iso-propyl, sec-butyl and tert-butyl orsellinates (8-10)--were less active than those with the correspondent linear chain. The activities presented by 4-methoxy-ethyl orsellinate (12) and ethyl orsellinate (3) suggest that the hydroxy group at the C-4 position causes effect in the cytotoxic activity of orsellinates against Artemia salina.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resorcinóis / Sobrevivência Celular / Líquens Limite: Animals Idioma: En Revista: Z Naturforsch C J Biosci Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resorcinóis / Sobrevivência Celular / Líquens Limite: Animals Idioma: En Revista: Z Naturforsch C J Biosci Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha