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Effect of sex steroids on the circulating levels of alpha 2-macroglobulin in injured rats.
Hirai, C Y; Limãos, E A.
Afiliação
  • Hirai CY; Departamento de Fisiologia, Escola Paulista de Medicina, São Paulo, SP, Brasil.
Braz J Med Biol Res ; 23(10): 1021-4, 1990.
Article em En | MEDLINE | ID: mdl-1713521
The effect of sex steroids on the plasma levels of alpha 2-macroglobulin (alpha 2-M) was investigated to explain the sexual dimorphism observed in response to the injury caused by ip administration of 5 micrograms endotoxin. Mean serum alpha 2-M concentrations were lower in female (46.82 +/- 8.10 arbitrary units) than in male injured rats (82.94 +/- 9.22 arbitrary units). A reduction of plasma alpha 2-M levels was observed after orchidectomy, and the administration of 1 mg testosterone to the same animals increased the response. The same response pattern was observed in ovariectomized rats under the same treatment. The response of androgenized rats (78.93 +/- 12.81 arbitrary units) to injury was similar to the male response. These results suggest the importance of testosterone as the major determinant of this sex-dependent response.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônios Esteroides Gonadais / Alfa-Macroglobulinas / Caracteres Sexuais / Reação de Fase Aguda Limite: Animals Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 1990 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônios Esteroides Gonadais / Alfa-Macroglobulinas / Caracteres Sexuais / Reação de Fase Aguda Limite: Animals Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 1990 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil