Effect of sex steroids on the circulating levels of alpha 2-macroglobulin in injured rats.
Braz J Med Biol Res
; 23(10): 1021-4, 1990.
Article
em En
| MEDLINE
| ID: mdl-1713521
The effect of sex steroids on the plasma levels of alpha 2-macroglobulin (alpha 2-M) was investigated to explain the sexual dimorphism observed in response to the injury caused by ip administration of 5 micrograms endotoxin. Mean serum alpha 2-M concentrations were lower in female (46.82 +/- 8.10 arbitrary units) than in male injured rats (82.94 +/- 9.22 arbitrary units). A reduction of plasma alpha 2-M levels was observed after orchidectomy, and the administration of 1 mg testosterone to the same animals increased the response. The same response pattern was observed in ovariectomized rats under the same treatment. The response of androgenized rats (78.93 +/- 12.81 arbitrary units) to injury was similar to the male response. These results suggest the importance of testosterone as the major determinant of this sex-dependent response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônios Esteroides Gonadais
/
Alfa-Macroglobulinas
/
Caracteres Sexuais
/
Reação de Fase Aguda
Limite:
Animals
Idioma:
En
Revista:
Braz J Med Biol Res
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil