In vitro studies on the release of isoniazid incorporated in poly(epsilon-caprolactone).
J Chemother
; 18(5): 473-9, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-17127222
A polymeric micro- and nanosphere formulation using poly (epsilon-caprolactone) (PCL) to entrap an antituberculosis drug, isoniazid (INH), was developed and characterized. The microspheres were prepared by a solvent evaporation method using ethyl acetate, PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. The nanospheres were prepared by a spontaneous emulsification solvent diffusion method using 40% ethanol in acetone (v/v), PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. After freeze-drying, these systems were characterized by scanning electron microscopy (SEM), particle size analysis, determination of entrapped INH content, in vitro INH release and brine shrimp toxicity bioassay.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caproatos
/
Nanotubos
/
Composição de Medicamentos
/
Isoniazida
/
Lactonas
/
Microesferas
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
J Chemother
Assunto da revista:
ANTINEOPLASICOS
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido