Analgesic activity of affinin, an alkamide from Heliopsis longipes (Compositae).
J Ethnopharmacol
; 110(2): 364-7, 2007 Mar 21.
Article
em En
| MEDLINE
| ID: mdl-17113736
Heliopsis longipes (Compositae) is a Mexican plant used as analgesic in pain toothache. A solution of 10mug/ml of dichloromethane extract from this plant showed analgesic activity determined by means of GABA release in mice brain slices. Through a bioassay-directed separation, fractions G-1, G-2, G-4 and G-6 at the same concentration were active. Affinin was the unique and common active compound, and evoke the GABA release 0.5min after administration at 1x10(-4)M concentration. Inactive compound were undeca-2E-en-8,10-dyinoic acid isobutylamide, hinokinin, 2'-hydroxyhinokinin, 3beta-sn-glyceroyl-(1''-palmitoxy)urs-12-ene, 13(18)-ursen-3beta-ol, 13(18)-ursen-3beta-acetate, beta-sitosterol and stigmasterol. The analgesic activity of Heliopsis longipes could be associated to affinin.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Extratos Vegetais
/
Asteraceae
/
Alcenos
/
Alcamidas Poli-Insaturadas
/
Amidas
/
Analgésicos
Limite:
Animals
País/Região como assunto:
Mexico
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Irlanda