EspC, an autotransporter protein secreted by enteropathogenic Escherichia coli (EPEC), displays protease activity on human hemoglobin.
FEMS Microbiol Lett
; 265(1): 35-40, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17107418
Some enteropathogenic Escherichia coli (EPEC) strains, which are an important cause of diarrhea among infants, secrete a serine protease autotransporter protein called EspC. The pathogenic role of EspC upon EPEC infection is unknown. In this study, we demonstrated that purified EspC protein, obtained from supernatants of EPEC cultures, interacted with hemoglobin and degraded it. Moreover, we have shown that EspC is a hemin-binding protein. We hypothesized that hemoglobin proteolysis by EspC may contribute to the utilization of heme and hemoglobin iron for bacterial growth.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas
/
Serina Endopeptidases
/
Proteínas de Escherichia coli
/
Escherichia coli
Limite:
Humans
Idioma:
En
Revista:
FEMS Microbiol Lett
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Reino Unido