Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase.
J Org Chem
; 71(23): 8685-90, 2006 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-17080994
Three new disulfated meroterpenoids, ilhabelanol (1), ilhabrene (2), and isoakaterpin (3), have been isolated from extracts of the Brazilian marine sponge Callyspongia sp. Isoakaterpin (3) inhibits Leishmania spp. adenosine phosphoribosyl transferase with an IC50 of 1.05 microM. The structures of 1, 2, and 3 were elucidated by analysis of one- and two-dimensional NMR data. Ilhabelanol (1) and ilhabrene (2) both have unprecedented meroterpenoid carbon skeletons.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
Adenina Fosforribosiltransferase
/
Callyspongia
/
Inibidores Enzimáticos
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2006
Tipo de documento:
Article
País de publicação:
Estados Unidos