Configuration and leishmanicidal activity of (-)-argentilactone epoxides.
Nat Prod Res
; 20(11): 1008-14, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-17050183
Epoxidation of argentilactone (1) with m-chloroperbenzoic acid gave a diasteromeric mixture of 2 and 3 in a ratio 1.8 : 1, with total yield 60%. The configuration of 7,8-oxirane ring for both diasteromers was determined by NMR analysis. Reaction of 1 with urea hydrogen peroxide gave the 3,4-epoxide (4) in 65% yield. The in vitro activity of 2, 3, 4 and argentilactone against Leishmania amazonensis was tested, only epoxides (2) and (3) showed leishmanicidal effect.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Epóxi
/
Lactonas
/
Leishmania
/
Antiprotozoários
Limite:
Animals
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Reino Unido