Zinc phthalocyanine/magnetic fluid complex: a promising dual nanostructured system for cancer treatment.
J Nanosci Nanotechnol
; 6(8): 2432-7, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-17037852
In this study we evaluated the photophysical, photochemical properties of the zinc phthalocyanine/ magnetic fluid (ZnPC/MF) complex in liposomal medium. As a result of the present investigation we propose the liposome-encapsulated ZnPC/MF complex as a very promising nanostructured device for cancer treatment. The spectroscopy characterization and the in vitro dark toxicity of both ZnPC and ZnPC/MF complex in Hank's and in liposomal medium are reported. Our findings revealed that the spectroscopic properties of the ZnPC associated or not with MF presented little differences and are very close to what one expects from an ideal photosensitizer compound. Indeed, the ZnPC/MF complex in liposomal medium presented lower dark toxicity compared to the ZnPC/MF complex in Hank's, strongly supporting the use of the former for cancer treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Portadores de Fármacos
/
Nanotecnologia
/
Indóis
/
Magnetismo
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Nanosci Nanotechnol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos