Substance P and naloxone enhancement of avoidance conditioning in rats.
Braz J Med Biol Res
; 23(2): 163-7, 1990.
Article
em En
| MEDLINE
| ID: mdl-1698492
Experiments were carried out to investigate the effects of peripheral post-training administration of substance P (SP) and naloxone on learning. Rats were trained in three different avoidance tasks (uphill, step-down and alcove) and tested 24 h later. Thirty minutes before each trial (training and testing) rats received naloxone (0.5, 1, 5, or 50 mg/kg, ip) or saline. SP (50 micrograms/kg) or vehicle was administered ip immediately after training. Animals that received SP and SP in combination with naloxone (5 and 50 mg/kg) showed significantly better retention test performance for the uphill and step-down avoidance (P less than 0.05 when compared to control rats treated with vehicle). In the alcove task no influence of SP and/or naloxone was demonstrable, probably due to a ceiling effect. These results suggest that the memory enhancement effects observed are mediated, at least in part, via interactions between substance P and the endogenous opioid systems.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retenção Psicológica
/
Aprendizagem da Esquiva
/
Substância P
/
Naloxona
Limite:
Animals
Idioma:
En
Revista:
Braz J Med Biol Res
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil