Effects of beta-carboline alkaloids on the object recognition task in mice.
Life Sci
; 79(22): 2099-104, 2006 Oct 26.
Article
em En
| MEDLINE
| ID: mdl-16904699
beta-carboline alkaloids are found in several medicinal plants and display a variety of actions on the central nervous, muscular and cardiovascular systems. The aim of the present study was to evaluate the effects of systemic administration of beta-carboline alkaloids on object recognition in mice. Adult Swiss mice received an intra-peritoneal injection (i.p.) of alkaloids (1.0, 2.5 or 5.0 mg/kg) 30 min before training in an object recognition task. The fully aromatic beta-carbolines, harmine and harmol, induced an enhancement of short-term memory (STM) at all doses tested when compared to controls. Harmaline, a dihydro beta-carboline and inverse agonist of the MK-801 binding site on the N-methyl-d-aspartate (NMDA) receptor, also induced an enhancement of both short-term memory (STM) and long-term memory (LTM). These results demonstrate that systemic administration of beta-carboline alkaloids can improve object recognition memory in mice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbolinas
/
Reconhecimento Psicológico
/
Alcaloides
/
Harmalina
/
Harmina
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda