Bracken-fern extracts can be clastogenic or aneugenic depending on the tissue cell assay.
Food Chem Toxicol
; 44(11): 1845-8, 2006 Nov.
Article
em En
| MEDLINE
| ID: mdl-16893598
The consumption of bracken fern (Pteridium aquilinum) as food is associated with a high incidence of cancer in humans and animals. We investigated the cytogenetic effects of bracken-fern extracts (hexane extract-HE, ethanol extract-EE, hot water extract-HWE and cold water extract-CWE) on chromosomes of peritoneal and bone-marrow cells of Swiss mice. In peritoneal cells, all four treatments (HE, EE, HWE and CWE) induced structural chromosome aberrations, but the EE also induced numerical chromosome aberrations. In bone-marrow cells both HE and CWE induced structural chromosome aberrations; additionally, the number of abnormal metaphases was higher in peritoneum than in bone marrow. We suggest that bracken fern induces cytogenetic damage through DNA strand breaks and affects chromosome segregation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células da Medula Óssea
/
Extratos Vegetais
/
Quebra Cromossômica
/
Pteridium
/
Aneuploidia
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Mutagênicos
Limite:
Animals
Idioma:
En
Revista:
Food Chem Toxicol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido