Your browser doesn't support javascript.
loading
In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women.
Nicol, A F; Nuovo, G J; Wang, Y; Grinsztejn, B; Tristão, A; Russomano, F; Perez, M A; Lapa e Silva, J R; Fernandes, A T G; Gage, J R; Martínez-Maza, O; Bonecini-Almeida, M G.
Afiliação
  • Nicol AF; Immunology Service of Evandro Chagas Clinical Research Institute, IPEC, FIOCRUZ, Avenue Brazil 4365 Manguinhos, Rio de Janeiro, CEP 21045-900, Brazil. nicol@ioc.fiocruz.br
Exp Mol Pathol ; 81(1): 42-7, 2006 Aug.
Article em En | MEDLINE | ID: mdl-16878360
The purpose of this study was to look for associations between a newly described class of suppressors of cytokine signaling (SSI/SOCS) and cytokine expression in the uterine cervix from HIV/HPV coinfected women. We examined the pro-inflammatory cytokines TNF-alpha and IL-6 since their expressions are linked and responsible for many aspects of both localized and systemic inflammatory responses. Further, expression of SSI/SOCS has been implicated in the negative feedback regulation of cytokine receptor signaling. PCR-amplified HIV-1 cDNA was noted mainly in the stroma, showing a perivascular distribution, and most of the infected cells colabeled with the macrophage marker CD68. The distribution of IL-6 and TNF-alpha was in the same area to HIV-1 and much greater than normal cervices from women with no evidence of viral infection. SOCS/SSI-1 and -3 mRNA positive cells in the uterine cervix were commonly detected in these noninfected cervical tissues; however, very few cells that contained SOCS were evident in areas where HIV-1, TNF-alpha, and IL-6 expressing cells were found. This suggests that viral-related suppression of SOCS/SSI-1-3 expression may be a factor in the marked local enhancement of TNF-alpha and IL-6 production which, in turn, may help facilitate viral spread; however, further studies should be done in order to elucidate the exact mechanisms of SOCS in the cervix.
Assuntos
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Infecções por HIV / Colo do Útero / Interleucina-6 / Fator de Necrose Tumoral alfa / Infecções por Papillomavirus / Proteínas Supressoras da Sinalização de Citocina Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans Idioma: En Revista: Exp Mol Pathol Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Infecções por HIV / Colo do Útero / Interleucina-6 / Fator de Necrose Tumoral alfa / Infecções por Papillomavirus / Proteínas Supressoras da Sinalização de Citocina Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans Idioma: En Revista: Exp Mol Pathol Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda