Your browser doesn't support javascript.
loading
Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: relationship with sTNFR2 levels and clinical features.
Oregón-Romero, Edith; Vázquez-Del Mercado, Mónica; Navarro-Hernández, Rosa Elena; Torres-Carrillo, Norma; Martínez-Bonilla, Gloria; Estrada-García, Iris; Rangel-Villalobos, Héctor; Muñoz-Valle, José Francisco.
Afiliação
  • Oregón-Romero E; Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
Rheumatol Int ; 27(1): 53-9, 2006 Nov.
Article em En | MEDLINE | ID: mdl-16871413
We investigate the clinical association of tumor necrosis factor receptor 2 (TNFR2) M196R polymorphism with rheumatoid arthritis (RA) and knee osteoarthritis (OA). Acute phase reactants, lipid profile, sTNFR2 levels, disease activity-disability indexes, and TNFR2 M196R polymorphism were analyzed in 50 RA, 50 knee OA patients, and 120 healthy subjects (HS). The M/M genotype frequency was 0.74 (RA), 0.80 (OA), and 0.64 (HS). The M/R genotype frequency was RA (0.26), OA (0.20), and HS (0.29). The R/R genotype was observed only in HS (0.07). The M allele was associated with OA (P = 0.0137, OR = 2.43). Total cholesterol, triglyceride levels, apolipoprotein A-I and B showed significant differences (P < 0.05). The highest sTNFR2 levels were observed in RA and OA (P = 0.001), however M/M and M/R carriers do not correlate with sTNFR2 production. Our findings suggest an association of the M allele with knee OA. In addition, high sTNFR2 levels in RA and OA were found.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Artrite Reumatoide / Índice de Gravidade de Doença / Osteoartrite do Joelho / Receptores Tipo II do Fator de Necrose Tumoral Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Rheumatol Int Ano de publicação: 2006 Tipo de documento: Article País de afiliação: México País de publicação: Alemanha
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Artrite Reumatoide / Índice de Gravidade de Doença / Osteoartrite do Joelho / Receptores Tipo II do Fator de Necrose Tumoral Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Rheumatol Int Ano de publicação: 2006 Tipo de documento: Article País de afiliação: México País de publicação: Alemanha